One of the new additions to Photoshop CS6 that will likely have slipped by you is a new addition to the way resizing images is handled. In the past, when using the Image Size dialog box to reduce an image’s size, you’d have to specify that you wanted Photoshop to use the Bicubic Sharper algorithm, which applies some sharpening to make images look their best when shrunk down. On top of that, it wasn’t a “sticky setting” - no matter how many times you selected that option, it Photoshop wouldn’t remember it, and you’d have to choose it every single time.
In CS6, although it’s still not sticky, Photoshop defaults to a new option called Bicubic Automatic. As you’d guess from the name, Photoshop intelligently chooses the best resampling algorithm for the job at hand (but you can still go in and override that choice if you like). As a bonus, Adobe has added the resampling options to a pull-down menu in the Options Bar of the Free Transform command.
(Kudos to you if you got the Public Enemy reference in the title of this post.)